Phenotypes Associated with This Genotype

Genotype
MGI:3721976

• Allelic Composition: Tg(Camk2a-IDE)1Selk/0; Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87150 )

• attenuated premature death at 6 months relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates

nervous system

gliosis ( J:87150 )

• microgliosis is reduced

astrocytosis ( J:87150 )

• decreased relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates

amyloid beta deposits ( J:87150 )

• at 6-10 months, soluble and insoluble Abeta-40 and -42 peptide levels are reduced by ~50% relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice; amyloid plaque burden is reduced by ~50%

abnormal neurite morphology ( J:87150 )

• number of dystrophic neurites is reduced relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice

homeostasis/metabolism

amyloid beta deposits ( J:87150 )

• at 6-10 months, soluble and insoluble Abeta-40 and -42 peptide levels are reduced by ~50% relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice; amyloid plaque burden is reduced by ~50%

cellular

gliosis ( J:87150 )

• microgliosis is reduced

astrocytosis ( J:87150 )

• decreased relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates