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Phenotypes Associated with This Genotype
Genotype
MGI:3721948
Allelic
Composition
Cd28tm1Shr/Cd28tm1Shr
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Shr mutation (4 available); any Cd28 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
in vitro T cell proliferation is reduced
• the number of CD4+ CD69+ T cells is reduced by 50% compared to in wild-type mice
• however, T and B cell development is normal
• upon primary stimulation in vitro, IL-2 production is decreased by 50% relative to in wild-type cells

hematopoietic system
in vitro T cell proliferation is reduced
• the number of CD4+ CD69+ T cells is reduced by 50% compared to in wild-type mice
• however, T and B cell development is normal

cellular
in vitro T cell proliferation is reduced


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory