Phenotypes Associated with This Genotype

Genotype
MGI:3721922

• Allelic Composition: Hhex^tm1Cwb/Hhex^tm2Cwb; Tg(Foxa3-cre)1Khk/?
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:124126 )

liver/biliary system

abnormal extrahepatic bile duct morphology ( J:124126 )

• at E13.5, the extrahepatic bile duct (EHBD) is absent and normal EHBD epithelium is replaced by pseudostratified epithelium resembling the duodenum

• at E16.5, the duodenal-like mucosa extends from the duodenum to the liver hilum

abnormal hepatic duct morphology ( J:124126 )

• at E16.5, dilated hepatic ducts and biliary cysts lined by cuboidal epithelium are present at the liver hilum

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

absent gallbladder ( J:124126 )

• at E10.5, gall bladder primordium could not be detected by Onecut1 staining

abnormal liver morphology ( J:124126 )

• at E16.5, the ventral liver periphery has lost its cohesive structure and bloods cells are trapped or pool in this region

• at E18.5, normal hepatic architecture is disrupted

abnormal intrahepatic bile duct morphology ( J:124126 )

• at E18.5, livers exhibit large dilated duct-like structures

liver cyst ( J:124126 )

• at E18.5, livers are extremely cystic with large dilated duct-like structures and many smaller cysts

liver hypoplasia ( J:124126 )

• at E13.5, the liver is hypoplastic

endocrine/exocrine glands

abnormal extrahepatic bile duct morphology ( J:124126 )

• at E13.5, the extrahepatic bile duct (EHBD) is absent and normal EHBD epithelium is replaced by pseudostratified epithelium resembling the duodenum

• at E16.5, the duodenal-like mucosa extends from the duodenum to the liver hilum

abnormal hepatic duct morphology ( J:124126 )

• at E16.5, dilated hepatic ducts and biliary cysts lined by cuboidal epithelium are present at the liver hilum

abnormal intrahepatic bile duct morphology ( J:124126 )

• at E18.5, livers exhibit large dilated duct-like structures

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

absent gallbladder ( J:124126 )

• at E10.5, gall bladder primordium could not be detected by Onecut1 staining

growth/size/body

biliary cyst ( J:124126 )

• at E16.5, biliary cysts are present at the liver hilum

liver cyst ( J:124126 )

• at E18.5, livers are extremely cystic with large dilated duct-like structures and many smaller cysts