Phenotypes Associated with This Genotype

Genotype
MGI:3721893

• Allelic Composition: Hoxa13^tm2Ipc/Hoxa13⁺; Hoxd13^tm1Ddu/Hoxd13⁺
• Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:36214 )

• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone

abnormal digit morphology ( J:36214 )

• digits I and V are deformed in the hinblimb

• digit I is more truncated than normal and no first phalanx is visible

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

• digits II and III are fused and alterations in the claw of digit I are observeddigits II and III are fused and alterations in the claw of digit I are observed

• newborn mice show an incomplete segmentation between phalangeal cartilage in digit I

abnormal phalanx morphology ( J:36214 )

• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

brachydactyly ( J:36214 )

• in adults, digits I, II and V are truncated

polydactyly ( J:36214 )

• 23 of 40 mice have an extra posterior digit in the forelimbs consisting of either a small floating bone distal to the post minimus or an entire small digit

interdigital webbing ( J:36214 )

• in adults, digits III and IV are partially fused in the forelimbs and digits II, III and IV are completely fused in the hindlimbs

elongated metatarsal bones ( J:36214 )

• the metatarsal of digit I is elongated

skeleton

abnormal carpal bone morphology ( J:36214 )

• in 50% of mice, the fourth posterior distal carpal bone is partly or fully split into two distinct bone

abnormal phalanx morphology ( J:36214 )

• digit I lacks a first phalanx and newborn mice show an incomplete segmentation between the two phalangeal cartilages in forelimbs and in some hindlimbs

• digit I in the hindlimb has its first phalanx truncated and the terminal phalanx has an altered bell-shaped morphology

• the second phalanges of digits II and mostly in digit V are truncated in the forelimbs and hindlimbs

elongated metatarsal bones ( J:36214 )

• the metatarsal of digit I is elongated