Mouse Genome Informatics
cx
    Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili

involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus
• at 12 months, mice have high levels of insoluble Abeta42
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals

other phenotype
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus
• at 12 months, mice have high levels of insoluble Abeta42
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:107702