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Phenotypes Associated with This Genotype
Genotype
MGI:3721542
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (64 available)
Tg(APPV717F)109Ili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus (J:107702)
• at 12 months, mice have high levels of insoluble Abeta42 (J:107702)
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals (J:107702)
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus (J:107702)
• at 12 months, mice have high levels of insoluble Abeta42 (J:107702)
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals (J:107702)

homeostasis/metabolism
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus (J:107702)
• at 12 months, mice have high levels of insoluble Abeta42 (J:107702)
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals (J:107702)
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus (J:107702)
• at 12 months, mice have high levels of insoluble Abeta42 (J:107702)
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals (J:107702)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:107702


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory