nervous system
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus
• at 12 months, mice have high levels of insoluble Abeta42
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals
|
homeostasis/metabolism
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus
• at 12 months, mice have high levels of insoluble Abeta42
• at 3 months, cerebral spinal fluid levels of Abeta40 and Abeta42 are elevated; Abeta40 increase is greater than in transgenic, Apoe-single null animals
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 |
OMIM:104300 OMIM:502500 OMIM:604154 OMIM:608907 |
J:107702 |