Phenotypes Associated with This Genotype

Genotype
MGI:3721542

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:107702 )

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex

• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus

• at 12 months, mice have high levels of insoluble Abeta₄₂

• at 3 months, cerebral spinal fluid levels of Abeta₄₀ and Abeta₄₂ are elevated; Abeta₄₀ increase is greater than in transgenic, Apoe-single null animals

homeostasis/metabolism

amyloid beta deposits ( J:107702 )

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex

• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus

• at 12 months, mice have high levels of insoluble Abeta₄₂

• at 3 months, cerebral spinal fluid levels of Abeta₄₀ and Abeta₄₂ are elevated; Abeta₄₀ increase is greater than in transgenic, Apoe-single null animals

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652	OMIM:104300 OMIM:502500 OMIM:604154 OMIM:608907	J:107702