• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex

• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus

• at 12 months, mice have high levels of insoluble Abeta₄₂

• at 3 months, cerebral spinal fluid levels of Abeta₄₀ and Abeta₄₂ are elevated; Abeta₄₀ increase is greater than in transgenic, Apoe-single null animals

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex

• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus

• at 12 months, mice have high levels of insoluble Abeta₄₂

• at 3 months, cerebral spinal fluid levels of Abeta₄₀ and Abeta₄₂ are elevated; Abeta₄₀ increase is greater than in transgenic, Apoe-single null animals