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Phenotypes Associated with This Genotype
Genotype
MGI:3721531
Allelic
Composition
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic
Background
Not Specified
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 12 months of age, ~60% of mice show amyloid beta (Abeta) deposition (J:78357)
• mice have a higher percentage of thioflavine-S positive Abeta-immunoreactive deposits than Clu-null mice (J:78357)
• all deposits are surrounded by multiple enlarged, dystrophic neurites (J:78357)
• a 2-fold increase in monomeric Abeta is detected in the brain compared to Clu-deficient transgenic mice (J:78357)
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)
• mice have prominent deposits that are both diffuse and compact in appearance in hippocampus and in molecular layer of dentate gyrus (J:107702)
• dystrophic neurites are 10-fold higher compared to Clu-null transgenic mice and more dystrophic neurites (5-fold) are associated with each amyloid deposit

homeostasis/metabolism
• 77% of mice have thioflavine-S-positive (fibrillar Abeta or amyloid) deposits in the cortex
• hippocampal amyloid burden is greater (2.76%) than in Clu-null transgenics at 12 months of age
• by 12 months of age, ~60% of mice show amyloid beta (Abeta) deposition (J:78357)
• mice have a higher percentage of thioflavine-S positive Abeta-immunoreactive deposits than Clu-null mice (J:78357)
• all deposits are surrounded by multiple enlarged, dystrophic neurites (J:78357)
• a 2-fold increase in monomeric Abeta is detected in the brain compared to Clu-deficient transgenic mice (J:78357)
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)
• mice have prominent deposits that are both diffuse and compact in appearance in hippocampus and in molecular layer of dentate gyrus (J:107702)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:78357


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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory