Phenotypes Associated with This Genotype

Genotype
MGI:3721441

• Allelic Composition: Cdk5r1^tm1Lht/Cdk5r1^tm1Lht; Cdk5r2^tm1Lht/Cdk5r2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:71181 )

• viability decreases with age, with mortality observed starting by P60

nervous system

nervous system phenotype ( J:71181 )

N • hippocampus is comparable to wild-type

abnormal hippocampus layer morphology ( J:71181 )

• diffuse laminar organization of CA pyramidal neurons; cell-free rifts appear less conspicuous than in double null animals

abnormal cerebellum morphology ( J:71181 )

• fissura secuda is less prominent than in wild-type or single-mutant cerebella at E18.5

small cerebellum ( J:71181 )

• decreased size relative to wild-type or single-null mice at E18.5