Analysis Tools
reproductive system
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• at all embryonic stages, germ cells tend to adhere together in clumps often at ectopic sites like the vitelline artery, while germ cells in heterozygotes and wild-type embryos are evenly distributed throughout the supporting somatic tissue
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• 9% of germ cells remain in the allantois at 9.5 days post coitum (dpc), while 22% are ectopic, in the vitelline artery or the mesenchyme surrounding it while in heterozygotes, only 1% remain in the allantois and 99% are found in the wall of the hindgut
• at 9.5 dpc, germ cells remain confined to the ventral half of the gut, whereas in heterozygotes and wild-type embryos, germ cells become distributed around entire circumference of the hindgut
• at 10.5 dpc, 39% of germ cells remain in the hindgut endothelium and none are found in the genital ridge, compared to heterozygotes and wild-type embryos where ~90% of germ cells have reached the genital ridge and only 10% remain in the hindgut
• migration of germ cells appears to be delayed at later stages of development (10.5 dpc), but is comparable to controls between 8.5 and 9.5 dpc
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• between 8.5 and 10.5 days post coitum (dpc), primordial germ cell numbers do not increase significantly, and remain at less than 100 compared to >725 in heterozygotes and wild-type embryos
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cellular
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• at all embryonic stages, germ cells tend to adhere together in clumps often at ectopic sites like the vitelline artery, while germ cells in heterozygotes and wild-type embryos are evenly distributed throughout the supporting somatic tissue
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• 9% of germ cells remain in the allantois at 9.5 days post coitum (dpc), while 22% are ectopic, in the vitelline artery or the mesenchyme surrounding it while in heterozygotes, only 1% remain in the allantois and 99% are found in the wall of the hindgut
• at 9.5 dpc, germ cells remain confined to the ventral half of the gut, whereas in heterozygotes and wild-type embryos, germ cells become distributed around entire circumference of the hindgut
• at 10.5 dpc, 39% of germ cells remain in the hindgut endothelium and none are found in the genital ridge, compared to heterozygotes and wild-type embryos where ~90% of germ cells have reached the genital ridge and only 10% remain in the hindgut
• migration of germ cells appears to be delayed at later stages of development (10.5 dpc), but is comparable to controls between 8.5 and 9.5 dpc
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• between 8.5 and 10.5 days post coitum (dpc), primordial germ cell numbers do not increase significantly, and remain at less than 100 compared to >725 in heterozygotes and wild-type embryos
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