Phenotypes Associated with This Genotype

Genotype
MGI:3721103

• Allelic Composition: F12^tm1Pbfd/F12^tm1Pbfd
• Genetic Background: B6.Cg-F12^tm1Pbfd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal response to CNS ischemic injury ( J:123758 )

• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice

• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected

decreased cerebral infarct size ( J:123758 )

• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

homeostasis/metabolism

abnormal response to CNS ischemic injury ( J:123758 )

• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice

• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected

decreased cerebral infarct size ( J:123758 )

• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor XII deficiency		DOID:2231	OMIM:234000	J:100529