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Phenotypes Associated with This Genotype
Genotype
MGI:3721103
Allelic
Composition
F12tm1Pbfd/F12tm1Pbfd
Genetic
Background
B6.Cg-F12tm1Pbfd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F12tm1Pbfd mutation (0 available); any F12 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice
• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected
• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

homeostasis/metabolism
• following transient cerebral ischemia, fibrin accumulation is less than in wild-type mice
• following transient cerebral ischemia, ischemic neurodegeneration associated with occlusions of vessel lumina is less severe than in wild-type mice and fewer occlusions are detected
• following transient cerebral ischemia, infarct size is reduced to less than 50% of that in wild-type mice and results in improved motor coordination and function relative to wild-type mice following injury

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
factor XII deficiency DOID:2231 OMIM:234000
J:100529


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory