Analysis Tools
mortality/aging
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• although mortality rates are greater than in wild-type mice, mice survive to one year
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nervous system
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• mice older than 3 months have a reduced brain size
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• at P21, activated microglia are detected in CA1 with a progression to CA3 and other regions of the hippocampus
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• at P12, pyramidal cell loss occurs in CA1 and progresses over the following weeks
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• the near complete loss of the hippocampus is due to hippocampus degeneration that begins at 2 weeks of age
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• the hippocampus is nearly completely replaced by a large cavity contiguous with the ventricular system
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• retinal degeneration leads to a complete loss of photoreceptors by P28
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• between P12 and P28, retinal degeneration affects both the photoreceptor inner and outer segment
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• at P12, the photoreceptor outer segment is disorganized
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• between P12 and P28, retinal degeneration affects both the photoreceptor inner and outer segment
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• the acidity in synaptic vesicles is lower than in wild-type vesicles
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• at P21, activated microglia are detected in CA1 with a progression to CA3 and other regions of the hippocampus
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• short-term plasticity is reduced without impaired excitability or excitation-inhibition balance
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behavior/neurological
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• locomotion is increased when mice are placed in a new environment compared to wild-type mice whose activity decreases with time spent in the new environment
• when placed in a new environment, mice exhibit increased running in circles with intermittent short stops over long periods
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• initially, mice exhibit a tremor when first put on a rod and perform poorly on a rotarod test but improve with time
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• when resting mice arch their backs
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• basal levels of locomotion are increased relative to those in wild-type mice and is accompanied by reduced resting time
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• when placed in a new environment, mice exhibit increased running in circles with intermittent short stops over long periods
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vision/eye
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• retinal degeneration leads to a complete loss of photoreceptors by P28
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• between P12 and P28, retinal degeneration affects both the photoreceptor inner and outer segment
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• at P12, the photoreceptor outer segment is disorganized
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• between P12 and P28, retinal degeneration affects both the photoreceptor inner and outer segment
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• retinal degeneration leads to a complete loss of photoreceptors by P28
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• in electroretinograms performed as soon as mice opened their eyes, mice either lacked an electrical response or showed a small wave that was not followed by a detectable b wave
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growth/size/body
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• except for immediately after birth mice are smaller in appearance and weight
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immune system
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• at P21, activated microglia are detected in CA1 with a progression to CA3 and other regions of the hippocampus
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renal/urinary system
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• mice exhibit normal urine homeostasis
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hematopoietic system
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• at P21, activated microglia are detected in CA1 with a progression to CA3 and other regions of the hippocampus
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