Phenotypes Associated with This Genotype

Genotype
MGI:3720951

• Allelic Composition: Bace1^tm1Pcw/Bace1^tm1Pcw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:116162 )

• mice show reduced grip strength (1.13) relative to wild-type controls (1.26)

decreased thermal nociceptive threshold ( J:116162 )

• mutants retract paws from thermal stimulus more rapidly than wild-type controls, indicating greater pain sensitivity

nervous system

abnormal myelin sheath morphology ( J:116162 )

• in 2-month old mice, myelin sheaths are significantly thinner in optic nerves compared to wild-type controls

• more axons in sciatic nerve of mutants appear smaller in diameter than in wild-type

abnormal myelination ( J:116162 )

• hypomyelination is observed in hippocampus and cerebral cortex at P15 and P30, but axonal development is normal

• sciatic nerve is hypomyelinated in mutants