Analysis Tools
behavior/neurological
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• mice are significantly impaired in Morris water maze tasks
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nervous system
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• high level of amyloid beta aggregates are found in brain at 12 months of age
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homeostasis/metabolism
amyloidosis
(
J:123534
)
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• in 12-month old brains, there is a 27% reduction in amyloid beta aggregates compared to transgenic mice that are wild-type for Bace1; there are no significant differences at 20 months
• in 12-month old brains, there is 37% reduction in percentage of brain volume occupied by amyloid beta deposits, but no difference at 20 months
|
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• high level of amyloid beta aggregates are found in brain at 12 months of age
|
