Phenotypes Associated with This Genotype

Genotype
MGI:3720944

• Allelic Composition: Bace1^tm1Pcw/Bace1^tm1Pcw; Tg(APP695)3Dbo/0; Tg(PSEN1dE9)S9Dbo/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:123534 )

N • mice perform as well as control mice in platform and probe trials in Morris water maze tasks

decreased anxiety-related response ( J:123534 )

• in open field test, mice are similar to Bace1^tm1Pcw homozygotes, and spend more time in open area at center of field than at periphery

abnormal locomotor activation ( J:123534 )

• swim speed is lower than other genotypes and nontransgenic mice in hidden and visible platform trials

nervous system

nervous system phenotype ( J:123534 )

N • in 12- or 20-month old mice, no amyloid beta (Abeta) aggregation is detected in brains; no amyloid deposits are found