Phenotypes Associated with This Genotype

Genotype
MGI:3720939

• Allelic Composition: Clcn3^tm1Lamb/Clcn3^tm1Lamb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:112692 )

• following surgery to implant a telemetry device to monitor blood pressure and heart rate, 90% of mice die whereas only 6% of wild-type mouse died from the same procedure

• pretreatment with antibiotics (enrofloxacin) reduces mortality following surgery to 50%

immune system

abnormal neutrophil physiology ( J:112692 )

• the maximum velocity of oxygen consumption and reactive oxygen species production in thioglycollate-elicited polymorphonuclear leukocytes (PMNs) treated with opsonized zymosan (OpZ) is decreased relative to in wild-type mice

• oxygen consumption in phorbol myristate acetate-treated PMNs is decreased

• anion selectivity is altered such that preference for chloride ions is equivalent to that for bromide ions whereas PMNs from wild-type mice have a stronger prefernece for chloride ions

impaired neutrophil phagocytosis ( J:112692 )

• polymorphonuclear leukocytes (PMNs) form fewer phagosomes compared to wild-type PMNs

sepsis ( J:112692 )

• following surgery to implant a telemetry device to monitor blood pressure and heart rate, mice develop signs of sepsis including lethargy, shivering, and progressive hypertension followed by death

nervous system

abnormal excitatory postsynaptic currents ( J:122982 )

• the excitatory postsynaptic current is smaller than in wild-type neurons

abnormal excitatory postsynaptic potential ( J:122982 )

• miniature excitatory postsynaptic potential (mEPSP) amplitude declines as a function of chloride ion concentration in contrast to in wild-type neurons

• miniature excitatory postsynaptic potential time constant is attenuated

• mEPSP decay constant is twice as short as in wild-type neurons

• mEPSP amplitude is decreased compared to that in wild-type neurons

• quantal content is decreased relative to that in wild-type neurons

hematopoietic system

abnormal neutrophil physiology ( J:112692 )

• the maximum velocity of oxygen consumption and reactive oxygen species production in thioglycollate-elicited polymorphonuclear leukocytes (PMNs) treated with opsonized zymosan (OpZ) is decreased relative to in wild-type mice

• oxygen consumption in phorbol myristate acetate-treated PMNs is decreased

• anion selectivity is altered such that preference for chloride ions is equivalent to that for bromide ions whereas PMNs from wild-type mice have a stronger prefernece for chloride ions

impaired neutrophil phagocytosis ( J:112692 )

• polymorphonuclear leukocytes (PMNs) form fewer phagosomes compared to wild-type PMNs

cellular

impaired neutrophil phagocytosis ( J:112692 )

• polymorphonuclear leukocytes (PMNs) form fewer phagosomes compared to wild-type PMNs