Phenotypes Associated with This Genotype

Genotype
MGI:3720886

• Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk; Ntf3^tm1Jae/Ntf3^tm1Jae
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent muscle spindles ( J:83461 )

• no muscle spindles are found in the soleus muscle during development and at later stages

abnormal dorsal root ganglion morphology ( J:83461 )

• the number of dorsal root ganglia neurons in L4 is increased by 50% relative to in wild-type mice

• while proprioceptive neurons are retained, the somata is reduced by 70%

abnormal proprioceptive neuron morphology ( J:83461 )

• proprioceptive neurons fail to innervate their target muscles

• proprioceptive axons fail to extend into the ventral horn

muscle

absent muscle spindles ( J:83461 )

• no muscle spindles are found in the soleus muscle during development and at later stages