Phenotypes Associated with This Genotype

Genotype
MGI:3720800

• Allelic Composition: Col1a2^oim/Col1a2⁺
• Genetic Background: B6C3Fe a/a-Col1a2^oim/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal compact bone morphology ( J:38013 )

• cortical bone consists of areas of normal lamellar bone intermixed with hypercellular, highly vascularized bone, however cortical thickness is normal

decreased bone strength ( J:38013 )

• although heterozygotes do not exhibit fractures, they show reduced bone mechanical strength

• male and female femurs have a 21% and 18% reduction in maximum load, respectively

• male and female femurs have a 32% and 39% reduction in energy to failure, respectively, compared to wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteogenesis imperfecta		DOID:12347	OMIM:PS166200	J:38013