Phenotypes Associated with This Genotype

Genotype
MGI:3720789

• Allelic Composition: Psen1^tm1Mpm/Psen1^tm1Mpm; Tg(APPSwe,tauP301L)1Lfa/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:107286 )

• Abeta oligomers begin to accumulate between 2 and 6 months of age, with continued age-dependent increase observed between 12 and 20 months

• intraneuronal oligomers are detected at 4-6 months of age

neurofibrillary tangles ( J:107286 )

• tau pathology is detected initially by 6 months of age, and tangle pathology is advanced by 20 months

homeostasis/metabolism

amyloid beta deposits ( J:107286 )

• Abeta oligomers begin to accumulate between 2 and 6 months of age, with continued age-dependent increase observed between 12 and 20 months

• intraneuronal oligomers are detected at 4-6 months of age