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Phenotypes Associated with This Genotype
Genotype
MGI:3720731
Allelic
Composition
Tg(Thy1-APP)3Somm/0
Genetic
Background
B6.Cg-Tg(Thy1-APP)3Somm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons
• axons that line the periphery of beta-amyloid plaques exhibit swelling unlike in wild-type mice
• entorhinal fibers extend outside the termination zone unlike in wild-type mice
• commissure axons extend into the outer molecular layer unlike in wild-type mice
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons

behavior/neurological
• at 3 months, mice exhibit lower light ambulation compared with wild-type mice
• at 6 months, mice exhibit increased in the ratio of dark to light ambulation during the second half of the active phase compared with wild-type mice
• at 12 months, circadian locomotor patterns are more constant than in wild-type mice
• at 12 months, mice exhibit increased dark and total ambulation compared with wild-type mice
• at 12 months, dark ambulation level is bimodal unlike in wild-type mice
• at 6 months during the first 2 hours
• impaired acquisition in the Morris water maze; the number of quadrant entries and the escape latencies are higher than in controls
• however, mutants are unaffected in open-field, elevated plus-maze, emergence tests, tests measuring motor coordination, during the probe trial and while swimming towards a visible platform
• in an isolation-induced/resident-intruder paradigm, mice exhibit a 4.6- and 59-fold increase in aggression at 6 and 12 months, respectively, compared with wild-type mice
• 67% of animals exhibit myoclonic jumping behavior in home cage
• reduced number of horizontal and vertical movements in the photocell monitor
• overnight at 12 months

growth/size/body
• 29% weight reduction compared to wild-type

homeostasis/metabolism
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:80449


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory