Mouse Genome Informatics
tg
    Tg(Thy1-APP)3Somm/0
B6.Cg-Tg(Thy1-APP)3Somm
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons
• axons that line the periphery of beta-amyloid plaques exhibit swelling unlike in wild-type mice
• entorhinal fibers extend outside the termination zone unlike in wild-type mice
• commissure axons extend into the outer molecular layer unlike in wild-type mice
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons

behavior/neurological
• at 3 months, mice exhibit lower light ambulation compared with wild-type mice
• at 6 months, mice exhibit increased in the ratio of dark to light ambulation during the second half of the active phase compared with wild-type mice
• at 12 months, circadian locomotor patterns are more constant than in wild-type mice
• at 12 months, mice exhibit increased dark and total ambulation compared with wild-type mice
• at 12 months, dark ambulation level is bimodal unlike in wild-type mice
• in an isolation-induced/resident-intruder paradigm, mice exhibit a 4.6- and 59-fold increase in aggression at 6 and 12 months, respectively, compared with wild-type mice
• at 6 months during the first 2 hours
• impaired acquisition in the Morris water maze; the number of quadrant entries and the escape latencies are higher than in controls
• however, mutants are unaffected in open-field, elevated plus-maze, emergence tests, tests measuring motor coordination, during the probe trial and while swimming towards a visible platform
• 67% of animals exhibit myoclonic jumping behavior in home cage
• reduced number of horizontal and vertical movements in the photocell monitor
• overnight at 12 months

growth/size/body
• 29% weight reduction compared to wild-type

homeostasis/metabolism
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:80449