Mouse Genome Informatics
involves: C57BL/6 * DBA/2 * SJL * SW
phenotype observed in females
phenotype observed in males
N normal phenotype
• progressive hindlimb weakness is observed

nervous system
• by 3 months of age, neurofibrillary tangles (NFTs) composed of straight fibers sometimes forming complex structures are detected in the spinal cords and pons of transgenic animals, and become more numerous with age; females develop pathology earlier than males
• levels of soluble endogenous and transgenic Tau protein are similar to double transgenic mice
• as severe as astrocytosis seen in Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc double transgenic mice in ventral diencepalon, hindbrain, and spinal cord
• Tau filaments occupy large proportion of cell volume, displacing nucleus and cytoplasmic organelles and compressing the Golgi apparatus
• dystrophic neurites reactive for APP epitopes are associated with amyloid plaques
• granulovacuolar degeneration is seen rarely in neurons of amygdala only

• increased eye irritation

Mouse Models of Human Disease
Alzheimer Disease; AD 104300 J:100965