Mouse Genome Informatics
tg
    Tg(APPSWE)2576Kha/0
involves: C57BL/6 * DBA/2 * SJL * SW
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• mice display amyloid plaques as early as 6 months, but do become numerous only in older mice (8.5 to 15 months)
• deposits contain both Abeta1-40 and Abeta1-42 peptides

other phenotype
• some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart
• amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen
• amyloid replaces most of the splenic red pulp
• in the liver, amyloid deposit is in the walls of sinusoids or central veins
• in the kidney, amyloid deposits are seen in the glomeruli
• amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A
• mice display amyloid plaques as early as 6 months, but do become numerous only in older mice (8.5 to 15 months)
• deposits contain both Abeta1-40 and Abeta1-42 peptides

renal/urinary system
• kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:174270