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Phenotypes Associated with This Genotype
Genotype
MGI:3720700
Allelic
Composition
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: C57BL/6 * DBA/2 * SJL * SW
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice display amyloid plaques as early as 6 months, but do become numerous only in older mice (8.5 to 15 months)
• deposits contain both Abeta1-40 and Abeta1-42 peptides

renal/urinary system
• kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla

homeostasis/metabolism
• some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart
• amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen
• amyloid replaces most of the splenic red pulp
• in the liver, amyloid deposit is in the walls of sinusoids or central veins
• in the kidney, amyloid deposits are seen in the glomeruli
• amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A
• mice display amyloid plaques as early as 6 months, but do become numerous only in older mice (8.5 to 15 months)
• deposits contain both Abeta1-40 and Abeta1-42 peptides

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:174270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory