Mouse Genome Informatics
tg
    Tg(APPSWE)2576Kha/0
involves: C57BL/6 * DBA/2 * SJL * SW
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• mice display amyloid plaques as early as 6 months, but do become numerous only in older mice (8.5 to 15 months)
• deposits contain both Abeta1-40 and Abeta1-42 peptides

renal/urinary system
• kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla

homeostasis/metabolism
• some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart
• amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen
• amyloid replaces most of the splenic red pulp
• in the liver, amyloid deposit is in the walls of sinusoids or central veins
• in the kidney, amyloid deposits are seen in the glomeruli
• amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A
• mice display amyloid plaques as early as 6 months, but do become numerous only in older mice (8.5 to 15 months)
• deposits contain both Abeta1-40 and Abeta1-42 peptides

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:174270