Mouse Genome Informatics
tg
    Tg(DMD-APP*)18Neve/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

immune system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

nervous system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice
• hippocampi contain numerous degenerating pyramidal and granule cells
• synaptic degeneration is evident throughout the hippocampi of 12-month old animals
• in ~1 year-old mice, numerous large lucent pyramidal neurons containing irregular cytoplasmic accumulations of atypical secondary lysosomes are observed, with comparable severity to ~2-year old Tg(DMD-APP*)7Neve mice
• mice show comparable degeneration at an earlier age (~1 year) than Tg(DMD-APP*)7Neve mice

homeostasis/metabolism
• hippocampi contain numerous degenerating pyramidal and granule cells

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:100978