About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3720677
Allelic
Composition
Tg(DMD-APP*)18Neve/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

immune system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

nervous system
• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice
• hippocampi contain numerous degenerating pyramidal and granule cells
• synaptic degeneration is evident throughout the hippocampi of 12-month old animals
• in ~1 year-old mice, numerous large lucent pyramidal neurons containing irregular cytoplasmic accumulations of atypical secondary lysosomes are observed, with comparable severity to ~2-year old Tg(DMD-APP*)7Neve mice
• mice show comparable degeneration at an earlier age (~1 year) than Tg(DMD-APP*)7Neve mice

homeostasis/metabolism
• hippocampi contain numerous degenerating pyramidal and granule cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:100978


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory