Phenotypes Associated with This Genotype

Genotype
MGI:3720601

• Allelic Composition: Reln^rl/Reln⁺
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:42417 )

N • cerebellum is normally foliated and qualitatively indistinguishable from that of wild-type controls

Purkinje cell degeneration ( J:42417 )

• males, but not females, have a 16% reduction in the number of Purkinje cells at 3 months of age and a 24% reduction at 16 months of age with the loss occurring throughout the mediolateral extent of the cerebellum

decreased Purkinje cell number ( J:42417 )

small cerebellum ( J:42417 )

• males, but not females, have reduction in overall cross-sectional area of the cerebella at 3 and 16 months of age