Phenotypes Associated with This Genotype

Genotype
MGI:3720485

• Allelic Composition: Dicer1^{Gt(RRF266)Byg}/Dicer1^{Gt(RRF266)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:108137 , J:123635 )

• at P0, 6% of pups are homozygous, less than the expected 25% (J:108137)

• however, no gross morphological abnormalities or changes in expression of imprinted genes are detected (J:108137)

• most mice die in utero due to defects in angiogenesis (J:123635)

• however, one homozygous male survived and was used to create additional homozygous mice (J:123635)

embryonic lethality during organogenesis, incomplete penetrance ( J:108137 )

• between E8.5 and E13.5, fewer homozygotes are found, 17% versus the expected 25%

immune system

increased susceptibility to Herpesvirales infection ( J:123635 )

• mice infected with herpes simplex type 1 (HSV-1) produce higher titers than wild-type mice

decreased susceptibility to Riboviria infection ( J:123635 )

• mice infected with lymphocytic choriomemingitis virus produce lower titers than in wild-type mice

increased susceptibility to Riboviria infection ( J:123635 )

• mice infected with vesicular stomatitis virus (VSV) produce higher titers than wild-type mice

• VSV titers in the brain are 100-fold greater than in wild-type mice

cardiovascular system

abnormal angiogenesis ( J:123635 )

• most mice die in utero due to defects in angiogenesis