Phenotypes Associated with This Genotype

Genotype
MGI:3720417

• Allelic Composition: Tg(APOE-DGAT1)1Far/0
• Genetic Background: involves: C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

liver inflammation ( J:124005 )

• phosphorylation levels of PERK, a kinase involved in the ER stress response, is increased relative to Tg(APOE-DGAT2)24Far mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:124005 )

N • plasma glucose and insulin levels are not increased relative to wild-type; mice have normal glucose and insulin tolerances

abnormal lipid level ( J:124005 )

• a 3.5-fold increase in ceramide levels in the liver is seen, but diacylglycerol content is similar to wild-type

abnormal fatty acids level ( J:124005 )

• higher levels of C18:1 and C18:2 fatty acyl-CoAs are found in livers of transgenic animals

increased liver triglyceride level ( J:124005 )

• 3-fold increase in liver triglyceride content is observed

liver/biliary system

increased liver triglyceride level ( J:124005 )

• 3-fold increase in liver triglyceride content is observed

liver inflammation ( J:124005 )

• phosphorylation levels of PERK, a kinase involved in the ER stress response, is increased relative to Tg(APOE-DGAT2)24Far mice