Analysis Tools
mortality/aging
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• at E10.5, 22 of 23 mice are dead
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embryo
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• at E9.5, only primary vasculature is present in the yolk sac
• mice fail to form secondary vessels and a well-organized network
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• at E9.5, 17 of 21 mice are smaller in size relative to controls
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• at E9.5, 17 of 21 mice are reduced in weight relative to controls
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• at E9.5, 7% of mice have an open neural tube
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• at E10, hemorrhage-forming pools of blood appear in the ectoplancental cone cavity and allantoic compartment
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• at E9.5, the chorion remains a compact structure
• chorion cell differentiation is blocked
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• trophoblast stem cells exhibit a delay in differentiation
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• at E9.5, the giant cell layer remains severely disorganized
• at E9.5 and E10.5, the giant cell layer is expanded
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• at E8.5, the ectoplacental cone persists and is wider at later stages
• at E10, hemorrhage-forming pools of blood appear in the ectoplancental cone cavity and allantoic compartment
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• at E9.5, the spongiotrophoblast layer remains severely disorganized
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• at E8.0, E8.5 and E10.5, the spongiotrophoblast layer is smaller
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• the umbilical cord fails to form
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• at E9.5
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• at E8.5, chorion and allantois approach but fail to fuse
• at E9.5, the chorioallantoic interface does not form
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nervous system
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• at E9.5, 7% of mice have an open neural tube
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• at E9.5
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• at E9.5, mice exhibit hindbrain hypoplasia
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• at E9.5, mice exhibit midbrain hypoplasia
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hematopoietic system
homeostasis/metabolism
cellular
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• at E9.5, mice exhibit an increase in apoptosis
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growth/size/body
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• at E9.5, 17 of 21 mice are smaller in size relative to controls
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• at E9.5, 17 of 21 mice are reduced in weight relative to controls
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cardiovascular system
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• at E9.5, only primary vasculature is present in the yolk sac
• mice fail to form secondary vessels and a well-organized network
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