Phenotypes Associated with This Genotype

Genotype
MGI:3720353

• Allelic Composition: Rag1/Rag2^tm1Mnz/Rag1/Rag2^tm1Mnz
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell morphology ( J:90487 )

• mutant thymocytes have an abnormal CD3 profile and are 97% TCR^lo compared to wild-type, suggesting failure of recombination at the TCR alpha locus in double-positive cells

abnormal double-negative T cell morphology ( J:90487 )

• a 20-30% increase in CD44- CD25+ cells is observed in mutants

abnormal double-positive T cell morphology ( J:90487 )

• Rag1 and Rag2 expression in double-positive T cells is decreased almost to limit of detection

decreased T cell number ( J:90487 )

• there are very few TCR^hi single-positive thymocytes

hematopoietic system

abnormal T cell morphology ( J:90487 )

• mutant thymocytes have an abnormal CD3 profile and are 97% TCR^lo compared to wild-type, suggesting failure of recombination at the TCR alpha locus in double-positive cells

abnormal double-negative T cell morphology ( J:90487 )

• a 20-30% increase in CD44- CD25+ cells is observed in mutants

abnormal double-positive T cell morphology ( J:90487 )

• Rag1 and Rag2 expression in double-positive T cells is decreased almost to limit of detection

decreased T cell number ( J:90487 )

• there are very few TCR^hi single-positive thymocytes