Phenotypes Associated with This Genotype

Genotype
MGI:3720350

• Allelic Composition: Pax5^tm1Mbu/Pax5^tm1Mbu
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:75504 )

• mice die at weaning

immune system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:139510 )

arrested B cell differentiation ( J:75504 )

• B cell development is arrested in the pro-B cell stage

abnormal B cell physiology ( J:123629 )

• in culture pro-B cells exhibit 32 times poorer adhesion to a VCAM-1 coated surface compared to wild-type cells

enhanced B cell migration ( J:123629 )

• in a transwell migration assay, pro-B cells have a 4-fold increase in migration towards a source of CXCL12 compared to wild-type mice

growth/size/body

postnatal growth retardation ( J:75504 )

cellular

decreased cell adhesion ( J:123629 )

• in culture pro-B cells exhibit 32 times poorer adhesion to a VCAM-1 coated surface compared to wild-type cells

enhanced B cell migration ( J:123629 )

• in a transwell migration assay, pro-B cells have a 4-fold increase in migration towards a source of CXCL12 compared to wild-type mice

hematopoietic system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:139510 )

arrested B cell differentiation ( J:75504 )

• B cell development is arrested in the pro-B cell stage

abnormal B cell physiology ( J:123629 )

• in culture pro-B cells exhibit 32 times poorer adhesion to a VCAM-1 coated surface compared to wild-type cells

enhanced B cell migration ( J:123629 )

• in a transwell migration assay, pro-B cells have a 4-fold increase in migration towards a source of CXCL12 compared to wild-type mice