Phenotypes Associated with This Genotype

Genotype
MGI:3720323

• Allelic Composition: Rab8a^tm1.2Aha/Rab8a^tm1.2Aha
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:123415 )

• mice die 3 to 4 weeks after birth

digestive/alimentary system

diarrhea ( J:123415 )

• at 2.5 to 3 weeks

abnormal small intestine morphology ( J:123415 )

• small intestines are swollen and contain undigested milk

decreased small intestinal microvillus size ( J:123415 )

• microvilli are shortened and contain inclusion bodies

abnormal intestinal absorption ( J:123415 )

• nutrient uptake is abolished in the small intestine

cellular

accumulation of giant lysosomes in kidney/renal tubule cells ( J:123415 )

• 2 to 2.5 weeks, lysosomes accumulate beneath the apical plasma membrane of the tubules

growth/size/body

cachexia ( J:123415 )

• at 2.5 to 3 weeks

renal/urinary system

accumulation of giant lysosomes in kidney/renal tubule cells ( J:123415 )

• 2 to 2.5 weeks, lysosomes accumulate beneath the apical plasma membrane of the tubules