Phenotypes for Lefty2 Nodal MGI:3720060 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lefty2^tm1Hmd/Lefty2^tm1Hmd Nodal^tm1Rob/Nodal⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6Cr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty2^tm1Hmd mutation (1 available); any Lefty2 mutation (14 available)
Nodal^tm1Rob mutation (2 available); any Nodal mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:57907 )

• mice die during late gastrulation

embryo

abnormal embryo development ( J:57907 )

• defects in embryogenesis due to a lack of Lefty2 are partially rescued although mice die in late gastrulation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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