Phenotypes Associated with This Genotype

Genotype
MGI:3720045

• Allelic Composition: Tg(CAG-APP)0304Shoj/0
• Genetic Background: involves: C3H * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:100977 )

N • no cerebral amyloid beta deposition is detected

amyloid beta deposits ( J:100977 )

• neurons in the brain, liver cells, intestinal epithelial cells, skeletal and heart muscle fibers, and adrenal gland contain detectable amounts of amyloid beta, and pancreatic acinar cells show highest levels

• all transgenic mice over 8 months of age show amyloid accumulation, particularly in the pancreas

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:100977 )

• some pancreatic acinar cells show degeneration with vacuoles; these cells appear to have inclusion body-like deposits

• in cytoplasm of acinar cells, vacuoles contain numerous nonbranching amyloid fibrils; such fibrils are also observed in large amounts in interstitial macrophages

• vacuoles also contain membranous debris and small vesicles

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:100977 )

• some pancreatic acinar cells show degeneration with vacuoles; these cells appear to have inclusion body-like deposits

• in cytoplasm of acinar cells, vacuoles contain numerous nonbranching amyloid fibrils; such fibrils are also observed in large amounts in interstitial macrophages

• vacuoles also contain membranous debris and small vesicles

immune system

abnormal circulating serum amyloid protein level ( J:100977 )

• in plasma, levels of Abeta 1-40 and Abeta 1-42 are 30-fold higher than in wild-type plasma

homeostasis/metabolism

amyloid beta deposits ( J:100977 )

• neurons in the brain, liver cells, intestinal epithelial cells, skeletal and heart muscle fibers, and adrenal gland contain detectable amounts of amyloid beta, and pancreatic acinar cells show highest levels

• all transgenic mice over 8 months of age show amyloid accumulation, particularly in the pancreas

abnormal circulating serum amyloid protein level ( J:100977 )

• in plasma, levels of Abeta 1-40 and Abeta 1-42 are 30-fold higher than in wild-type plasma