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Phenotypes Associated with This Genotype
Genotype
MGI:3719798
Allelic
Composition
En2tm1Alj/En2tm1Alj
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En2tm1Alj mutation (1 available); any En2 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• deficient performance in a hidden platform test
• reduced allogrooming among juveniles
• increased allogrooming among males rather than aggressive behavior
• while falling but not on a flat surface
• poor performance on rotarod tests
• from age 21-27 days
• latency to attack is increased in adult males
• significantly reduced social interactions (play) in juveniles
• hypoactivity
• less sniffing

homeostasis/metabolism
• increased serotonin in the cerebellum
• increased 5-hydroxyindolacetic acid in the cerebellum

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:114464


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory