Phenotypes Associated with This Genotype

Genotype
MGI:3719798

• Allelic Composition: En2^tm1Alj/En2^tm1Alj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:114464 )

• deficient performance in a hidden platform test

abnormal grooming behavior ( J:114464 )

decreased grooming behavior ( J:114464 )

• reduced allogrooming among juveniles

increased grooming behavior ( J:114464 )

• increased allogrooming among males rather than aggressive behavior

abnormal motor capabilities/coordination/movement ( J:114464 )

abnormal motor coordination/balance ( J:114464 )

impaired righting response ( J:114464 )

• while falling but not on a flat surface

impaired coordination ( J:114464 )

• poor performance on rotarod tests

abnormal grip strength ( J:114464 )

• deficient

hyperactivity ( J:114464 )

• from age 21-27 days

abnormal social/conspecific interaction behavior ( J:114464 )

decreased aggression towards mice ( J:114464 )

• latency to attack is increased in adult males

abnormal social investigation ( J:114464 )

• significantly reduced social interactions (play) in juveniles

• hypoactivity

• less sniffing

homeostasis/metabolism

increased serotonin level ( J:114464 )

• increased serotonin in the cerebellum

• increased 5-hydroxyindolacetic acid in the cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:114464