Mouse Genome Informatics
hm
    En2tm1Alj/En2tm1Alj
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• reduced allogrooming among juveniles
• increased allogrooming among males rather than aggressive behavior
• deficient performance in a hidden platform test
• while falling but not on a flat surface
• poor performance on rotarod tests
• from age 21-27 days
• latency to attack is increased in adult males
• significantly reduced social interactions (play) in juveniles
• hypoactivity
• less sniffing

homeostasis/metabolism
• increased serotonin in the cerebellum
• increased 5-hydroxyindolacetic acid in the cerebellum

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:114464