Phenotypes Associated with This Genotype

Genotype
MGI:3719676

• Allelic Composition: Igk^tm1Dhu/Igk^tm1Dhu; Iglc1^tm2Ust/Iglc1^tm2Ust
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B-1a cell number ( J:113218 )

• B-1a B cell numbers are increased relative to in Igk^tm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igk^tm1Dhu homozygotes and 18.5% in Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• the ratio of B1 to B2 cells is increased relative to Igk^tm1Dhu homozygotes

hematopoietic system

increased B-1a cell number ( J:113218 )

• B-1a B cell numbers are increased relative to in Igk^tm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igk^tm1Dhu homozygotes and 18.5% in Igk^tm1Dhu Igl-C1^tm1Ust homozygotes

• the ratio of B1 to B2 cells is increased relative to Igk^tm1Dhu homozygotes