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Phenotypes Associated with This Genotype
Genotype
MGI:3719658
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (2 available); any Igk mutation (33 available)
Iglc1tm1Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:68144 )
• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen
increased B cell number ( J:68144 )
• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

hematopoietic system
abnormal B cell differentiation ( J:68144 )
• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen
increased B cell number ( J:68144 )
• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory