Phenotypes Associated with This Genotype

Genotype
MGI:3719654

• Allelic Composition: Igk^tm1Dhu/Igk^tm1Dhu; Iglc1^tm1Ust/Iglc1^tm1Ust
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

• the ratios of lambda1 to lambda2/3 B cells in the bone marrow and spleen is increased to 14.9 and 11.9, respectively, from 1.5 and 1.1 in wild-type mice

• lambda1 B cells percentages are increased to 82% compared to 54% in wild-type mice

hematopoietic system

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

• the ratios of lambda1 to lambda2/3 B cells in the bone marrow and spleen is increased to 14.9 and 11.9, respectively, from 1.5 and 1.1 in wild-type mice

• lambda1 B cells percentages are increased to 82% compared to 54% in wild-type mice