Phenotypes Associated with This Genotype

Genotype
MGI:3719422

• Allelic Composition: Mbd4/Ift122^tm1Abc/Mbd4/Ift122^tm1Abc
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:86981 )

• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) fail to arrest at the G2-M checkpoint and exhibit a decrease in apoptosis

• MEFs are resistant to apoptosis induced by oxaliplatin, irinotecan and 5-fluorouracil

cellular

abnormal cell cycle checkpoint function ( J:86981 )

• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) fail to arrest at the G2-M checkpoint

decreased sensitivity to induced cell death ( J:86981 )

• following treatment with a methylating agent MNNG, mouse embryonic fibroblasts (MEFs) exhibit a decrease in apoptosis

• MEFs are resistant to apoptosis induced by oxaliplatin, irinotecan and 5-fluorouracil

• however, MEFs are susceptible to apoptosis induced by an amphotropic avian sarcoma virus-based vector