Mouse Genome Informatics
cx
    Gadd45atm1Ajf/Gadd45atm1Ajf
Xpctm1Ecf/Xpctm1Ecf

either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• at 24 months of age, only 28% of mutants are alive compared to 43% of wild-type

tumorigenesis
• some mutants exhibit malignant adenocarcinoma with metastasis to adjacent lymph nodes
• 100% of mutants develop lung tumors by 24 months of age; display a full range of lung lesions, ranging from mild atypia and hyperplasia to malignant adenocarcinoma with metastasis to adjacent lymph nodes
• majority of mutants develop lung adenocarcinomas coincident with adenomas

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:101421