About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3719353
Allelic
Composition
Gadd45atm1Ajf/Gadd45atm1Ajf
Xpctm1Ecf/Xpctm1Ecf
Genetic
Background
either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45atm1Ajf mutation (1 available); any Gadd45a mutation (7 available)
Xpctm1Ecf mutation (1 available); any Xpc mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 100% of mutants develop lung tumors by 24 months of age; display a full range of lung lesions, ranging from mild atypia and hyperplasia to malignant adenocarcinoma with metastasis to adjacent lymph nodes
• majority of mutants develop lung adenocarcinomas coincident with adenomas

mortality/aging
• at 24 months of age, only 28% of mutants are alive compared to 43% of wild-type

neoplasm
• some mutants exhibit malignant adenocarcinoma with metastasis to adjacent lymph nodes
• 100% of mutants develop lung tumors by 24 months of age; display a full range of lung lesions, ranging from mild atypia and hyperplasia to malignant adenocarcinoma with metastasis to adjacent lymph nodes
• majority of mutants develop lung adenocarcinomas coincident with adenomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
J:101421


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory