Phenotypes Associated with This Genotype

Genotype
MGI:3719290

• Allelic Composition: Xpc^tm1Ecf/Xpc^tm1Ecf
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lungs of Xpc^tm1Ecf/Xpc^tm1Ecf mice show a range of lesions

neoplasm

increased lung tumor incidence ( J:101421 )

• lung tumors are seen as early as 6 months of age and by 16-17 months of age, all mutants develop tumors

• incidence and multiplicity of lung tumors increases with age

increased lung adenoma incidence ( J:101421 )

• most lung tumors are classified as adenomas, with only a few progressing to malignant carcinomas

increased lung adenocarcinoma incidence ( J:101421 )

• a few lung tumors progress to malignant carcinomas

respiratory system

increased lung tumor incidence ( J:101421 )

• lung tumors are seen as early as 6 months of age and by 16-17 months of age, all mutants develop tumors

• incidence and multiplicity of lung tumors increases with age

increased lung adenoma incidence ( J:101421 )

• most lung tumors are classified as adenomas, with only a few progressing to malignant carcinomas

increased lung adenocarcinoma incidence ( J:101421 )

• a few lung tumors progress to malignant carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:101421