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Phenotypes Associated with This Genotype
Genotype
MGI:3719290
Allelic
Composition
Xpctm1Ecf/Xpctm1Ecf
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpctm1Ecf mutation (1 available); any Xpc mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lungs of Xpctm1Ecf/Xpctm1Ecf mice show a range of lesions

respiratory system
• lung tumors are seen as early as 6 months of age and by 16-17 months of age, all mutants develop tumors
• incidence and multiplicity of lung tumors increases with age
• most lung tumors are classified as adenomas, with only a few progressing to malignant carcinomas
• a few lung tumors progress to malignant carcinomas

neoplasm
• lung tumors are seen as early as 6 months of age and by 16-17 months of age, all mutants develop tumors
• incidence and multiplicity of lung tumors increases with age
• most lung tumors are classified as adenomas, with only a few progressing to malignant carcinomas
• a few lung tumors progress to malignant carcinomas

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:101421


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory