Phenotypes Associated with This Genotype

Genotype
MGI:3719091

• Allelic Composition: Sox8^tm1Weg/Sox8^tm1Weg; Sox9^tm2Crm/Sox9^tm2Crm; Tg(Nr5a1-cre)5Asc/?
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased Sertoli cell number ( J:89368 )

• at E18.5, Sertoli cells are absent

absent Leydig cells ( J:89368 )

• at E18.5, Leydig cells are absent

cryptorchism ( J:89368 )

• by E18.5 testes have not descended caudally

reproductive system

decreased Sertoli cell number ( J:89368 )

• at E18.5, Sertoli cells are absent

absent Leydig cells ( J:89368 )

• at E18.5, Leydig cells are absent

cryptorchism ( J:89368 )

• by E18.5 testes have not descended caudally

abnormal primary sex determination ( J:89368 )

• gonads develop very few or no sex chords

• XY males exhibit ovarian differentiation

sex reversal ( J:89368 )

• 1 in 3 male mice undergoes sex reversal