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Phenotypes Associated with This Genotype
Genotype
MGI:3719089
Allelic
Composition		 Sox9tm2Crm/Sox9tm2Crm
Tg(Nr5a1-cre)5Asc/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:89368 )
• at E18.5, mice have a significant number of meiotic gonocytes (prophase) located in the seminiferous tubules next to quiescent gonocytes whereas gonocyte meiosis is inhibited in wild-type mice
abnormal seminiferous tubule morphology ( J:89368 )
• gonads have fewer seminiferous cords and their outline is irregular
abnormal testis development ( J:89368 )
• at E13.5, male testis development is abnormal in a proportion of mice
• however, testes descend normally

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:89368 )
• gonads have fewer seminiferous cords and their outline is irregular
abnormal testis development ( J:89368 )
• at E13.5, male testis development is abnormal in a proportion of mice
• however, testes descend normally

cellular
abnormal male meiosis ( J:89368 )
• at E18.5, mice have a significant number of meiotic gonocytes (prophase) located in the seminiferous tubules next to quiescent gonocytes whereas gonocyte meiosis is inhibited in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory