Mouse Genome Informatics
hm
    Neu1a/Neu1a
SM/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• deficient enzymatic activity of neuraminidase was reported (J:43930)
• tissue specific decrease in sialidase activity (J:147881)

growth/size
• compared to C57BL/6 controls

liver/biliary system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

renal/urinary system
• some epithelial cells accumulate large membrane-bound structures containing membranous whorls
• cells with high levels of membranous accumulations degenerate releasing cellular debris into the intercellular space and the lumen of the tubules

hematopoietic system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

immune system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

cardiovascular system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

Mouse Models of Human Disease
OMIM IDRef(s)
Neuraminidase Deficiency 256550 J:77236