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Phenotypes Associated with This Genotype
Genotype
MGI:3719077
Allelic
Composition
Neu1a/Neu1a
Genetic
Background
SM/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neu1a mutation (1 available); any Neu1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• deficient enzymatic activity of neuraminidase was reported (J:43930)
• tissue specific decrease in sialidase activity (J:147881)

growth/size/body
• compared to C57BL/6 controls

liver/biliary system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

renal/urinary system
• some epithelial cells accumulate large membrane-bound structures containing membranous whorls
• cells with high levels of membranous accumulations degenerate releasing cellular debris into the intercellular space and the lumen of the tubules

hematopoietic system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

immune system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

cardiovascular system
• cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Neuraminidase Deficiency 256550 J:77236


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory