Phenotypes Associated with This Genotype

Genotype
MGI:3719018

• Allelic Composition: Tg(Col2a1-Mef2c/en)1Eno/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal pelvic girdle bone morphology ( J:119152 )

• shortening of the pelvis

abnormal thoracic cage morphology ( J:119152 )

short vertebral column ( J:119152 )

failure of endochondral bone ossification ( J:119152 )

• ossification in nearly every region of the endochondral skeleton is blocked, while formation of cartilage-independent membranous bones is unaffected; as a result, all endochondral bones are hypoplastic

• in the most strongly affected mutants, the endochondral bones at the base of the skull, hyoid bone, the bones of the limbs, the sternum, and the pelvis remain entirely cartilaginous

• chondrocyte hypertrophy is completely absent

limbs/digits/tail

short limbs ( J:119152 )