Phenotypes Associated with This Genotype

Genotype
MGI:3719016

• Allelic Composition: Mef2c^tm1Eno/Mef2c^tm2Eno; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased length of long bones ( J:119152 )

• truncation of all long bones of the limbs

abnormal endochondral bone ossification ( J:119152 )

• structures of the distal ribs, radii, and sternabrae are distorted by disorganized cartilaginous remnants of the growth plate and aberrant ossification

failure of sternum ossification ( J:119152 )

• absence of ossification of the sternum and a failure in chondrocyte hypertrophy

behavior/neurological

abnormal gait ( J:119152 )

• waddling gait due to shortened limbs

limbs/digits/tail

short limbs ( J:119152 )

• truncation of all long bones of the limbs