Phenotypes Associated with This Genotype

Genotype
MGI:3718779

• Allelic Composition: Atg4c^tm1Otin/Atg4c^tm1Otin
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired autophagy ( J:123386 )

• after 24 hour starvation autophagic activity was significantly decreased in the diaphragm muscle compared to wild-type control

• mice are viable and fertile otherwise indicating that they are able to develop the autophagic response required during the early neonatal period

• a reduced autophagic degradation in adult fibroblast in culture under starvation conditions

behavior/neurological

decreased locomotor activity ( J:123386 )

• after prolonged starvation, the locomotor activity of mutant mice was significantly reduced

neoplasm

increased incidence of tumors by chemical induction ( J:123386 )

• an increased susceptibility to develop fibrosarcomas induced by intradermal injection of the MCA carcinogen

• mutant mice do not develop more spontaneous tumors than their wild-type littermates

homeostasis/metabolism

impaired autophagy ( J:123386 )

• after 24 hour starvation autophagic activity was significantly decreased in the diaphragm muscle compared to wild-type control

• mice are viable and fertile otherwise indicating that they are able to develop the autophagic response required during the early neonatal period

• a reduced autophagic degradation in adult fibroblast in culture under starvation conditions

increased incidence of tumors by chemical induction ( J:123386 )

• an increased susceptibility to develop fibrosarcomas induced by intradermal injection of the MCA carcinogen

• mutant mice do not develop more spontaneous tumors than their wild-type littermates