Phenotypes Associated with This Genotype

Genotype
MGI:3718590

• Allelic Composition: Ncaph2^nes/Ncaph2^nes; Tg(TcrHEL3A9)1Mmd/0
• Genetic Background: C57BL/6-Ncaph2^nes Tg(TcrHEL3A9)1Mmd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:123300 )

• decrease in the proportion of double positive cells and increase in the proportion of DN4 cells

abnormal double-negative T cell morphology ( J:123300 )

• increase in the proportion of double negative T cell progenitors with high levels of CD44 expression in the thymus

decreased double-positive T cell number ( J:123300 )

• decrease in the proportion of double positive cells in the thymus similar to homozygous mice not expressing the prearranged T cell receptor transgene

hematopoietic system

abnormal thymus cell ratio ( J:123300 )

• decrease in the proportion of double positive cells and increase in the proportion of DN4 cells

abnormal double-negative T cell morphology ( J:123300 )

• increase in the proportion of double negative T cell progenitors with high levels of CD44 expression in the thymus

decreased double-positive T cell number ( J:123300 )

• decrease in the proportion of double positive cells in the thymus similar to homozygous mice not expressing the prearranged T cell receptor transgene

endocrine/exocrine glands

abnormal thymus cell ratio ( J:123300 )

• decrease in the proportion of double positive cells and increase in the proportion of DN4 cells