Mouse Genome Informatics
involves: 129S2/SvPas
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• mice spend less time per entry into dark arms than controlsmice spend less time per entry into dark arms than controls
• mice exit dark side of dark-light box more often than controls
• exploratory behavior is increased for both familiar and novel objects
• at 5.5 months of age, mice do not appear to recall platform position from the previous day of training and show a lower learning rate over subsequent trials
• impairment observed at 10 months of age
• at 9 months, a delay of learning process in Morris water maze is observed compared to controls
• transgenic mice display more spontaneous locomotor activity than controls; activity is higher than in Tg(APP)8.9Btla or Tg(SOD1)51Yg mice

• little or no perturbation of the retinas structure or cornea is observed (J:80534)
• numerous bodies with circular profiles are present in all lens sections examined
• circles are present in lenses from mice >6 months of age; circles are 1-5 um in diameter
• lenses from 6 and 16 month-old mice contain swollen cortical fiber cells and lens plaques
• fiber cell nuclei are disorganized in the outer cortical region compared to wild-type
• lens degeneration is variable in severity and onset; in some cases, one lens is more severely affected than the other side
• individual fiber cells are irregularly shaped and fiber cell arrays are misaligned
• lens fiber cell membranes are morphologically abnormal
• mice display age-related fiber cell degeneration and cortical plaque formation

nervous system
• no Abeta peptides are detected in 5 month old mice (J:96742)

Mouse Models of Human Disease
Alzheimer Disease; AD 104300 J:96742