Phenotypes Associated with This Genotype

Genotype
MGI:3718514

• Allelic Composition: Tg(APP)8.9Btla/Tg(APP)8.9Btla; Tg(SOD1)69Yg/Tg(SOD1)69Yg
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:96742 )

• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials

impaired short-term object recognition memory ( J:96742 )

• impairment observed at 10 months of age in Morris water maze

abnormal spatial learning ( J:96742 )

• at 9 months, a delay of learning process in Morris water maze is observed compared to controls

• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired

nervous system

abnormal excitatory postsynaptic potential ( J:96742 )

• mice display depotentiation to a smaller EPSP size

reduced long-term potentiation ( J:96742 )

• LTP is impaired

homeostasis/metabolism

amyloidosis ( J:96742 )

• mic show a 1.6-fold increase of cortical APP proteins and a 1.8-2.1-fold increase in hippocampal APP levels compared to Tg(APP)8.9Btla mice