Phenotypes Associated with This Genotype

Genotype
MGI:3718509

• Allelic Composition: Tg(SOD1)51Yg/Tg(SOD1)51Yg
• Genetic Background: involves: BALB/c * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:96742 )

• mice are smaller than Tg(SOD1)69Yg mice

decreased body weight ( J:96742 )

• weight is lower than controls or Tg(SOD1)69Yg mice

behavior/neurological

decreased anxiety-related response ( J:96742 )

• mice spend less time in the closed arms than controls; time/entry is lower than in controls as well

• mice exit dark side of dark-light box more often than controls

abnormal physical strength ( J:96742 )

• exhibit lower muscular strength than non-transgenic control mice

abnormal locomotor activation ( J:96742 )

• transgenic mice display more spontaneous locomotor activity than controls

abnormal pain threshold ( J:96742 )

• lower pain thresholds than non-transgenic controls

nervous system

reduced long-term potentiation ( J:96742 )

• LTP is impaired