Phenotypes for Otx2 MGI:3718488 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Otx2^tm2.1Imat/Otx2^tm7Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm2.1Imat mutation (0 available); any Otx2 mutation (50 available)
Otx2^tm7Sia mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:91012 )

N	• axis rotation occurs normally

nervous system

abnormal forebrain development ( J:91012 )

• at E12.5, forebrain defects range from mild to severe

absent midbrain ( J:91012 )

• at E12.5, in severe cases the midbrain is absent

absent forebrain ( J:91012 )

• in some cases the forebrain is absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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