Analysis Tools
nervous system
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• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
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• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type
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• between 4 and 7 days in culture, total dendritic length of mutant neurons is less than in wild-type; after 7 days in culture, neurons still lag behind wild-type showing more developmental delay
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behavior/neurological
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• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice
• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice
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cellular
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• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type
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