Phenotypes for Hdac1 Hdac2 Tg(Myh6-cre)2182Mds MGI:3718388 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Hdac2^tm1.1Eno/Hdac2^tm1.1Eno Tg(Myh6-cre)2182Mds/?
Genetic Background	involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1^tm1.1Eno mutation (0 available); any Hdac1 mutation (36 available)
Hdac2^tm1.1Eno mutation (0 available); any Hdac2 mutation (38 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:123173 )

• mice die by day 14

cardiovascular system

dilated heart ventricle ( J:123173 )

• at P11, left and right ventricles are dilated

irregular heartbeat ( J:123173 )

• at P10, mice display cardiac arrhythmias

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

muscle

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

cellular

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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