Phenotypes for Hdac1 Hdac2 Tg(Myh6-cre)2182Mds MGI:3718388 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Hdac2^tm1.1Eno/Hdac2^tm1.1Eno Tg(Myh6-cre)2182Mds/?
Genetic Background	involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1^tm1.1Eno mutation (0 available); any Hdac1 mutation (38 available)
Hdac2^tm1.1Eno mutation (0 available); any Hdac2 mutation (39 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:123173 )

• mice die by day 14

cardiovascular system

dilated heart ventricle ( J:123173 )

• at P11, left and right ventricles are dilated

irregular heartbeat ( J:123173 )

• at P10, mice display cardiac arrhythmias

muscle

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

cellular

increased cardiomyocyte apoptosis ( J:123173 )

• mice have a three-fold increase in apoptosis compared to wild-type and control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/20/2026 MGI 6.24